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related tumour simulation

dataset
posted on 2021-08-16, 05:53 authored by Sebastian Hollizeck, Stephen WongStephen Wong, BENJAMIN SOLOMONBENJAMIN SOLOMON, Dineika Chandrananda, SARAH-JANE DAWSONSARAH-JANE DAWSON
Simulated dataset of related tumour samples.

Reads were firsts simulated with ART then aligned with BWA and variants were spiked in with Bamsurgeon.

Truth variants were split into somatic (simulating a cancer like allele frequency distribution) and germline (actual sample germline variants at a 0.5 allele frequency)


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