Supplementary figure 1: Impact of excess activin A on the lipids, metabolites, and steroids of adult mousereproductive organs

Figure S1: Activin A immunolocalization in adult mouse organs. Activin A was immunolocalised in the WT InhaKO testes. Strong signal was observed in Sertoli cells (Ser.), spermatogonia (S), primary spermatogonia (PS), and heterogeneously within the interstitial regions (Int) of the WT testes, with strongest staining in the testis macrophages (M). In the InhaKO, strong signal was observed in a similar distribution, and strongly within regions of histological abnormality. In the ovary, a strong signal is detected in antral and developing follicles (Fol.), a weak signal detected in Stroma (S), and a moderate signal detected in corpora lutea (CL). In the InhaKO ovary, signal is detected in all follicles, regions of abnormality (*), and a stronger signal is detected in the ovarian stroma. In the male adrenal gland, activin A signal is detected strongly in the adrenal cortex (Cx), x-zone (X), and less intensely in the medulla (M). No medulla sections were captured in the wild-type adrenal glands.