Understanding how Alzheimer's Work: Structural Investigation of copper binding in N-truncated Amyloid-beta using X-ray absorption Fine Structure.

This reseach work reveals the stucture of Cu(II) binding site in N-truncated Amyloid-beta (4-9,12,16) peptide. Xray absorption spectroscopy of Cu(II) Amyloid-beta _(4-9,12,16) peptides under electrochemical contron allowed to explore the redox properties of copper ion in the peptide. The reduction of Cu(II) in to Cu(I) is significantly enhanced by involvement of bis-his (H₁₃H₁₄) binding motif.